                               SEQUENCE LISTING	

<110> DA SILVA, FREDERICO NUNO CASTANHEIRA AIRES 
      CORTE-REAL, SOFIA VOLKER 
      DA SILVA ALBUQUERQUE E FREITAS, RUI PEDRO  
      FERREIRA LLORENTE GRANCHO LOURENCO, SARA 
 
<120> ANTI-TUMOR NECROSIS FACTOR-ALPHA AGENTS AND USES THEREOF

<130> 14116-105011P1

<140>
<141>

<160> 61    

<170> PatentIn version 3.5

<210> 1
<211> 111
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 1
Glu Leu Val Leu Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu 
            100                 105                 110     


<210> 2
<211> 110
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 2
Glu Leu Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg Gly 
                85                  90                  95      


Ser Val Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210> 3
<211> 107
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 3
Glu Leu Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Met Lys Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Gly Tyr Tyr Ser Ala Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Asn Val Glu Ile Lys 
            100                 105         


<210> 4
<211> 111
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 4
Glu Leu Asp Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Ser Ser Ser Ser 
                85                  90                  95      


Arg Tyr Gly Asn Gly Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu 
            100                 105                 110     


<210> 5
<211> 110
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 5
Glu Leu Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile Ser Ser Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Thr Tyr Thr Asn 
                85                  90                  95      


Ile Glu Asn Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu 
            100                 105                 110 


<210> 6
<211> 108
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 6
Glu Leu Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Ala Cys Gln Cys Thr Gly Tyr Gly Ser Asp 
                85                  90                  95      


Trp Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105             


<210> 7
<211> 108
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 7
Glu Leu Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Ser Asn Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Met Lys Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Gly Tyr Tyr Ser Ala Gly 
                85                  90                  95      


Ala Thr Phe Gly Ala Gly Thr Asn Val Glu Ile Lys 
            100                 105             


<210> 8
<211> 107
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 8
Glu Leu Asp Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Ser Asn Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Met Lys Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Gly Tyr Tyr Ser Ala Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Asn Val Glu Ile Lys 
            100                 105         


<210> 9
<211> 111
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 9
Glu Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Pro Ser Val Tyr Lys Asn 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Leu Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Gly Asp Ile 
                85                  90                  95      


Asp Asp Thr His Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu 
            100                 105                 110     


<210> 10
<211> 106
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 10
Glu Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Val Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Arg His Lys Pro Arg Gln Pro Pro Gln Leu Leu Ile 
        35                  40                  45              


Gly Ala Ser Asn Leu Glu Ser Gly Val Ala Ser Trp Phe Arg Gly Arg 
    50                  55                  60                  


Gly Ser Gly Thr Gly Ile Asn Leu Thr Ile Thr Gly Met Lys Ala Glu 
65                  70                  75                  80  


Asp Val Ala Ala Tyr Tyr Cys Tyr Arg His Ser Asn Cys Tyr Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Asn Val Glu Ile Lys 
            100                 105     


<210> 11
<211> 109
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 11
Glu Leu Asp Leu Thr Gln Thr Pro Pro Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Arg Ile Arg Cys Leu Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Glu Lys Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Ser Arg Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Gly Gly Val Gln Thr 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Ser Tyr Gly Ser Thr 
                85                  90                  95      


Gly Met Thr Phe Gly Ala Gly Thr Asn Val Glu Ile Lys 
            100                 105                 


<210> 12
<211> 109
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 12
Glu Leu Val Met Thr Gln Thr Pro Pro Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Arg Ile Arg Cys Leu Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Thr Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Gly Gly Val Gln Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Thr Tyr Ser Gly 
                85                  90                  95      


Thr Leu Thr Phe Gly Ala Gly Thr Asn Val Glu Ile Lys 
            100                 105                 


<210> 13
<211> 111
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 13
Glu Leu Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Gly Asn Asn 
            20                  25                  30          


Tyr Leu Cys Trp Tyr Gln Lys Lys Arg Gly Pro Pro Pro Met Leu Leu 
        35                  40                  45              


Ile Tyr Lys Ala Ser Pro Leu Ala Ser Gly Val Pro Ser Arg Phe Glu 
    50                  55                  60                  


Gly Gly Gly Ser Gly Thr Glu Tyr Pro Leu Thr Ile Gly Gly Val Arg 
65                  70                  75                  80  


Gly Asp Asp Ala Ala Ser Tyr Cys Cys Gln Gly Tyr Ile Gly Tyr Asn 
                85                  90                  95      


Asn Asp Asp His Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210> 14
<211> 112
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 14
Glu Leu Val Leu Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Val Ala Ile Ser Gly 
                85                  90                  95      


Asn Ser Tyr Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


<210> 15
<211> 108
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 15
Glu Leu Asp Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Ser Asn Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Met Lys Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Gly Tyr Tyr Ser Ala Gly 
                85                  90                  95      


Ala Thr Phe Gly Ala Gly Thr Asn Val Glu Ile Lys 
            100                 105             


<210> 16
<211> 107
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 16
Glu Leu Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Tyr Ser Gly Gly Ser Ile Tyr 
                85                  90                  95      


Ser Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu 
            100                 105         


<210> 17
<211> 110
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 17
Glu Leu Asp Leu Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Ala Gly Ser Ser 
                85                  90                  95      


Tyr Gly Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210> 18
<211> 109
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 18
Glu Leu Asp Met Thr Gln Thr Pro Ser Pro Val Ser Gly Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Ile Gly Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Asp Tyr Thr Asp Asn Ser 
                85                  90                  95      


Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 


<210> 19
<211> 111
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 19
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys 
            100                 105                 110     


<210> 20
<211> 111
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 20
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys 
            100                 105                 110     


<210> 21
<211> 111
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 21
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys 
            100                 105                 110     


<210> 22
<211> 111
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 22
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys 
            100                 105                 110     


<210> 23
<211> 111
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 23
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys 
            100                 105                 110     


<210> 24
<211> 110
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 24
Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Asn Arg Gly 
                85                  90                  95      


Ser Val Ala Ser Phe Gly Gly Gly Thr Lys Val Val Val Lys 
            100                 105                 110 


<210> 25
<211> 110
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 25
Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Asn Arg Gly 
                85                  90                  95      


Ser Val Ala Ser Phe Gly Gly Gly Thr Lys Val Val Val Lys 
            100                 105                 110 


<210> 26
<211> 110
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 26
Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg Gly 
                85                  90                  95      


Ser Val Ala Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys 
            100                 105                 110 


<210> 27
<211> 110
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 27
Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg Gly 
                85                  90                  95      


Ser Val Ala Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys 
            100                 105                 110 


<210> 28
<211> 110
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Rabbit polypeptide

<400> 28
Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg Gly 
                85                  90                  95      


Ser Val Ala Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys 
            100                 105                 110 


<210> 29
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly 
        


<210> 30
<211> 52
<212> PRT
<213> Streptococcus zooepidemicus

<400> 30
Asp Ile Thr Gly Ala Ala Leu Leu Glu Ala Lys Glu Ala Ala Ile Asn 
1               5                   10                  15      


Glu Leu Lys Gln Tyr Gly Ile Ser Asp Tyr Tyr Val Thr Leu Ile Asn 
            20                  25                  30          


Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Ala Glu Ile Leu 
        35                  40                  45              


Ser Ala Leu Pro 
    50          


<210> 31
<211> 52
<212> PRT
<213> Streptococcus zooepidemicus

<400> 31
Asp Ile Thr Gly Ala Ala Leu Leu Glu Ala Lys Asp Ala Ala Ile Asn 
1               5                   10                  15      


Glu Leu Lys Gln Tyr Gly Ile Ser Asp Tyr Tyr Val His Leu Ile Asn 
            20                  25                  30          


Lys Ala Asp Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu Ile Leu 
        35                  40                  45              


Ser Ala Leu Pro 
    50          


<210> 32
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Glu Leu Val Leu Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Arg 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
        195                 200                 205             


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
225                 230                 235                 


<210> 33
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Glu Leu Val Leu Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Arg 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
        195                 200                 205             


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                245                 250                 255     


Gly Asp Ile Thr Gly Ala Ala Leu Leu Glu Ala Lys Asp Ala Ala Ile 
            260                 265                 270         


Asn Glu Leu Lys Gln Tyr Gly Ile Ser Asp Tyr Tyr Val His Leu Ile 
        275                 280                 285             


Asn Lys Ala Asp Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu Ile 
    290                 295                 300                 


Leu Ser Ala Leu Pro 
305                 


<210> 34
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Glu Leu Val Leu Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Arg 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
        195                 200                 205             


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                245                 250                 255     


Gly Asp Ile Thr Gly Ala Ala Leu Leu Glu Ala Lys Asp Ala Ala Ile 
            260                 265                 270         


Asn Glu Leu Lys Gln Tyr Gly Ile Ser Asp Tyr Tyr Val His Leu Ile 
        275                 280                 285             


Asn Lys Ala Asp Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu Ile 
    290                 295                 300                 


Leu Ser Ala Leu Pro 
305                 


<210> 35
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys 
        195                 200                 205             


Ser Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ser Phe Gly Gly Gly Thr Lys Val Val Val Lys 
225                 230                 235                 


<210> 36
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys 
        195                 200                 205             


Ser Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ser Phe Gly Gly Gly Thr Lys Val Val Val Lys 
225                 230                 235                 


<210> 37
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys 
        195                 200                 205             


Ser Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys 
225                 230                 235                 


<210> 38
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys 
        195                 200                 205             


Ser Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys 
225                 230                 235                 


<210> 39
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys 
        195                 200                 205             


Ser Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys 
225                 230                 235                 


<210> 40
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys 
        195                 200                 205             


Ser Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ser Phe Gly Gly Gly Thr Lys Val Val Val Lys Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                245                 250                 255     


Gly Asp Ile Thr Gly Ala Ala Leu Leu Glu Ala Lys Asp Ala Ala Ile 
            260                 265                 270         


Asn Glu Leu Lys Gln Tyr Gly Ile Ser Asp Tyr Tyr Val His Leu Ile 
        275                 280                 285             


Asn Lys Ala Asp Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu Ile 
    290                 295                 300                 


Leu Ser Ala Leu Pro 
305                 


<210> 41
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys 
        195                 200                 205             


Ser Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ser Phe Gly Gly Gly Thr Lys Val Val Val Lys Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                245                 250                 255     


Gly Asp Ile Thr Gly Ala Ala Leu Leu Glu Ala Lys Asp Ala Ala Ile 
            260                 265                 270         


Asn Glu Leu Lys Gln Tyr Gly Ile Ser Asp Tyr Tyr Val His Leu Ile 
        275                 280                 285             


Asn Lys Ala Asp Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu Ile 
    290                 295                 300                 


Leu Ser Ala Leu Pro 
305                 


<210> 42
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Val Ser Thr Arg Ala Ser Gly Val Ser Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys 
        195                 200                 205             


Ser Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                245                 250                 255     


Gly Asp Ile Thr Gly Ala Ala Leu Leu Glu Ala Lys Asp Ala Ala Ile 
            260                 265                 270         


Asn Glu Leu Lys Gln Tyr Gly Ile Ser Asp Tyr Tyr Val His Leu Ile 
        275                 280                 285             


Asn Lys Ala Asp Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu Ile 
    290                 295                 300                 


Leu Ser Ala Leu Pro 
305                 


<210> 43
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Val Ser Thr Glu Ala Ser Gly Val Ser Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys 
        195                 200                 205             


Ser Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                245                 250                 255     


Gly Asp Ile Thr Gly Ala Ala Leu Leu Glu Ala Lys Asp Ala Ala Ile 
            260                 265                 270         


Asn Glu Leu Lys Gln Tyr Gly Ile Ser Asp Tyr Tyr Val His Leu Ile 
        275                 280                 285             


Asn Lys Ala Asp Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu Ile 
    290                 295                 300                 


Leu Ser Ala Leu Pro 
305                 


<210> 44
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Glu Leu Val Leu Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Gly Thr 
                85                  90                  95      


Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Gly Glu Leu Val Met Thr Gln Gln Pro Ala Ser Val Glu Ala Ala Pro 
    130                 135                 140                 


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Lys 
        195                 200                 205             


Ser Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Val Asn Arg 
    210                 215                 220                 


Gly Ser Val Ala Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                245                 250                 255     


Gly Asp Ile Thr Gly Ala Ala Leu Leu Glu Ala Lys Asp Ala Ala Ile 
            260                 265                 270         


Asn Glu Leu Lys Gln Tyr Gly Ile Ser Asp Tyr Tyr Val His Leu Ile 
        275                 280                 285             


Asn Lys Ala Asp Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu Ile 
    290                 295                 300                 


Leu Ser Ala Leu Pro 
305                 


<210> 45
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Gly Gly Gly Gly Ser 
1               5   


<210> 46
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Gly Gly Ser Gly 
1               


<210> 47
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Gly Gly Ser Gly Gly Ser 
1               5       


<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210> 49
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 51
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 52
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 53
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Ser Gly Gly Gly Gly Ser Ser Gly 
1               5               


<210> 55
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly 
        


<210> 56
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Gly 
            20              


<210> 57
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly 
            20                  25              


<210> 58
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Ser Gly 
        35              


<210> 59
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
1               5                   10                  15      


Pro Thr Pro Thr Ser 
            20      


<210> 60
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 60
His His His His His His 
1               5  


<210> 61
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


